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1    Kok DJ, Papapoulos SE, Bijvoet OLM. Excessive crystal agglomeration with low citrate excretion in recurrent stone formers. The Lancet 1986; i: 1056‑1058.
2    Kok DJ, Papapoulos SE, Bijvoet OLM. Low inhibition of crystal agglomeration and citrate excretion in recurrent calcium oxalate stone formers. Contrib to Nephrology1987; 58: 73‑77.
3    Kok DJ, Papapoulos SE, Bijvoet OLM. Modulation of calcium oxalate monohydrate growth kinetics in vitro. Kidney Int 1988; 34: 346‑350.
4    Kok DJ, Papapoulos SE, Bijvoet OLM. Crystal agglomeration is a major element in calcium oxalate urinary stone formation. Kidney Int 1990; 37: 51-56.
5    Kok DJ, Iestra J, Doorenbos JC, Papapoulos SE. The effects of chronic dietary loads with salt and animal protein on the calcium oxalate crystallization kinetics in urines of healthy men. J Clin Endocrin Metab, 1990; 71: 861-867.
6    Cao LC, Boevé ER, Schröder FH, Robertson WG, Ketelaars GA, de Bruijn WC. The effect of two new semi-synthetic glycosaminoglycans (G871, G872) on the zeta potential of calcium oxalate crystals and on growth and agglomeration. J Urol. 1992 147: 1643-6.
7   Kok DJ, Papapoulos SE. Physicochemical considerations in development and prevention of calcium oxalate urolithiasis, a review. Bone and Mineral 1993; 20: 1-15.
8    Kok DJ, Poindexter J, Pak CYC. Calculation of titratable acidity. Kidney Int, 1993; 44: 120-126.
9    Cao LC, Boevé ER, de Bruijn WC, Robertson WG, Schröder FH. A review of new concepts in renal stone research. Scanning Microsc. 1993; 7: 1049-64; discussion 1064-5.
10      De Bruijn WC, Ketelaars GA, Boevé ER, Sorber CW, Cao LC, Schröder FH.Electron energy-loss spectroscopical and image analysis of experimentally induced rat microliths. II. J Urol. 1993; 149: 900-5.
11      Boevé ER, Ketelaars GA, Vermeij M, Cao LC, Schröder FH, De Bruijn WC. An ultrastructural study of experimentally induced microliths in rat proximal and distal tubules. J Urol. 1993; 149: 893-9.
12      Verkoelen CF, Romijn JC, de Bruijn WC, Boevé ER, Cao LC, Schröder FH. Absence of a transcellular oxalate transport mechanism in LLC-PK1 and MDCK cells cultured on porous supports. Scanning Microsc. 1993; 7: 1031-8; discussion 1038-40.
13      Kok DJ, Khan SR. Calcium oxalate Nephrolithiasis, a free or fixed particle disease. Kidney Int, 1994; 46: 847-854.
14      Erwin DT, Kok DJ, Alam J, Cole FE et al. Predicting Recurrent Renal Stone formation and Therapy using crystal agglomeration inhibition. Am J Kidney Dis   1994; 24: 893-900.
15      Boevé ER, Cao LC, Verkoelen CF, Romijn JC, de Bruijn WC, Schröder FH. Glycosaminoglycans and other sulphated polysaccharides in calculogenesis of urinary stones. World J Urol. 1994; 12: 43-8.
16      de Bruijn WC, Boevé ER, van Run PR, van Miert PP, Romijn JC, Verkoelen CF, Cao LC, Schröder FH. Etiology of experimental calcium oxalate monohydrate nephrolithiasis in rats. Scanning Microsc. 1994; 8: 541-9; discussion 549-50.
17      Boevé ER, Cao LC, De Bruijn WC, Robertson WG, Romijn JC, Schröder FH. Zeta potential distribution on calcium oxalate crystal and Tamm-Horsfall protein surface analyzed with Doppler electrophoretic light scattering. J Urol. 1994; 152: 531-6.
18      Breslau NA, Padalino P, Kok DJ, Kim YG, Pak CYC. Physicochemical effects of a new slow-release potassium phosphate preparation (urophos-K) in absorptive hypercalciura. J Bone Min Res 1995; 10: 394-400.
19      Fuselier HA, Cole FE, Kok DJ et al. Urinary Tamm-Horsfall Protein increased after potassium citrate therapy in calcium stone formers. Urology 1995; 45: 942-946.
20      Verkoelen CF, Romijn JC, de Bruijn WC, Boevé ER, Cao LC, Schröder FH. Association of calcium oxalate monohydrate crystals with MDCK cells. Kidney Int. 1995; 48: 129-38.
21      de Bruijn WC, Boevé ER, van Run PR, van Miert PP, de Water R, Romijn JC, Verkoelen CF, Cao LC, van 't Noordende JM, Schrder FH. Etiology of calcium oxalate nephrolithiasis in rats. II. The role of the papilla in stone formation. Scanning Microsc. 1995; 9: 115-24; discussion 124-5.
22      de Bruijn WC, Boevé ER, van Run PR, van Miert PP, de Water R, Romijn JC, Verkoelen CF, Cao LC, Schröder FH. Etiology of calcium oxalate nephrolithiasis in rats. I. Can this be a model for human stone formation? Scanning Microsc. 1995; 9: 103-14.
23      Kok DJ. Free and fixed particle mechanism, a review. Scanning Electron Microscopy 1996; 10: 471-486.
24      de Water R, Boevé ER, van Miert PP, Deng G, Cao LC, Stijnen T, de Bruijn WC, Schröder FH. Experimental nephrolithiasis in rats: the effect of ethylene glycol and vitamin D3 on the induction of renal calcium oxalate crystals. Scanning Microsc. 1996; 10: 591-601; discussion 601-3.
25      de Water R, Boevé ER, van Miert PP, Vermaire CP, van Run 14: Pathological and immunocytochemical changes in chronic calcium oxalate nephrolithiasis in the rat. Scanning Microsc. 1996; 10: 577-87; discussion 587-90.
26      Boevé ER, Cao LC, Deng G, De Bruijn WC, Schröder FH. Effect of two new polysaccharides on growth, agglomeration and zeta potential of calcium phosphate crystals. J Urol. 1996; 155: 368-73.
27      Verkoelen CF, Romijn JC, Cao LC, Boevé ER, De Bruijn WC, Schröder FH. Crystal-cell interaction inhibition by polysaccharides. J Urol. 1996; 155: 749-52.
28      de Bruijn WC, de Water R, Boevé ER, van Run PR, Vermaire PJ, van Miert PP, Romijn JC, Verkoelen CF, Cao LC, Schröder FH. Lectin-cytochemistry of experimental rat nephrolithiasis. Scanning Microsc. 1996; 10: 557-76.
29      Cao LC, Deng G, Boevé ER, de Bruijn WC, de Water R, Verkoelen CF, Romijn JC, Schröder FH. Zeta potential measurement and particle size analysis for a better understanding of urinary inhibitors of calcium oxalate crystallization. Scanning Microsc. 1996; 10: 401-11
30      Verkoelen CF, Romijn JC. Oxalate transport and calcium oxalate renal stone disease. Urol Res. 1996; 24: 183-91.
31      Kok DJ. Intratubular crystallization events. World J Urol 1997; 15: 219-228.
32      Cao LC, Kok DJ et al. Gags and semisynthetic sulfated polysaccharides: An overview of their potential application in treatment of patients with uro- thiasis.Urology 1997; 50: 173-183.
33      De Bruijn WC, Kok DJ et al. Ultrastructural osteopontin localization in papillary stones induced in rats. Eur Urol 1997; 32: 360-367.
34      Verkoelen CF, van der Boom BG, Schröder FH, Romijn JC. Cell cultures and nephrolithiasis. World J Urol. 1997 ;15: 229-35.
35      Cao LC, Deng G, Boevé ER, Romijn JC, de Bruijn WC, Verkoelen CF, Schröder FH. Does urinary oxalate interfere with the inhibitory role of glycosaminoglycans and semisynthetic sulfated polysaccharides in calcium oxalate crystallization? Eur Urol. 1997; 31: 485-92.
36      Fuselier HA, Moore K, Lindberg J, et al.Agglomeration inhibition reflected stoneforming activity during long-term potassium citrate therapy in calcium stoneformers Urology 1998; 52: 988-994.
37      Verkoelen CF, van der Boom BG, Houtsmuller AB, Schröder FH, Romijn JC. Increased calcium oxalate monohydrate crystal binding to injured renal tubular epithelial cells in culture. Am J Physiol. 1998; 274: F958-65.
38      de Water R, Noordermeer C, Kok DJ et al. Calcium oxalate nephrolithiasis: Effect of renal crystal deposition on the cellular composition of the renal interstitium. Am J Kidney Dis 1999; 33: 761-771.
39      Verkoelen CF, Kok DJ, et al. Cell type-specific acquired protection from crystal adherence by renal tubule cells in culture. Kidney Int 1999; 55: 1426-1433.
40      Verkoelen CF, Kok DJ, van der Boom BG, et al.LLC-PK1 cells as a model system to study proximal tubule transport of water and other compounds relevant for renal stone disease. Urol Res 1999; 27: 109-115.
41      Kok DJ, Schell-Feith. Risk factors for crystallization in the nephron: the role of renal development. J Am Soc Nephrol 1999; 10: S364-370
42      Verkoelen CF, Kok DJ et al.. Attachment sites for particles in the urinary tract. J Am Soc Nephrol, 1999; 10: S430-435.
43      Verkoelen CF, Kok DJ et al.. Sialic acid and crystal binding. Kidney Int, 2000; 57: 1072-1082.
44      Lindberg JS, Cole FE, Romani W, Husserl FE, Fuselier HA, Kok DJ, Erwin DT. Calcium oxalate stone agglomeration inhibition [tm] reflects renal stone forming activity. The Oschner Journal 2000; 2: 68-79.
45      Mathoera RB, Kok DJ, Nijman RJ. Bladder calculi in augmentation cystoplasty in children. Urology 2000;56; 482-7.
46      R. de Water, C. Noordermeer, A.B. Houtsmuller, D.J. Kok, H. Nizze, F.H. Schröder. The role of macrophages in Nephrolithiasis in rats: An analysis of the renal interstitium. Am J Kidney Dis 2000; 36: 615-625.
47      Verkoelen CF, Schepers MS.Changing concepts in the aetiology of renal stones. Curr Opin Urol. 2000; 10: 539-44.
48      Verkoelen CF, Van Der Boom BG, Romijn JC. Identification of hyaluronan as a crystal-binding molecule at the surface of migrating and proliferating MDCK cells. Kidney Int. 2000 Sep;58(3):1045-54.
49      de Water R, Leenen PJM, Noordermeer C, Nigg AL, Houtsmuller AB, Kok DJ, Schröder FH. Macrophages in nephrolithiasis: cytokine production induced by binding and processing of calcium oxalate crystals. Am J Kidney Dis 2001; 38: 331-338.
50      Salahuddin S, Hsu YS, Buchholz NP, Dieleman JP, Gyssens IC, Kok DJ. Is Indinavir crystalluria an indicator for indinavir stone formation? AIDS 2001; 15: 1079-1080
51      Dieleman JP, Salahuddin S, Hsu YS, Burher DM, Gyssens IC, Sturkenboom MCJM, Stricker BHCh, Kok DJ. Indinavir crystallisation under loop of Henle conditions: experimental evidence. J Acq Immun Def Synd 2001; 28: 9-13
52      Schell-Feith EA, Que I, Kok DJ, Kist-van Holthe JE, Kühler E, Brand R, Papapoulos SE, vd Heijden BJ. Modulation of calcium oxalate monohydrate crystallization kinetics by urine of preterm neonates. Am J Kidney Dis, 2001; 38: 1229-1234.
53      Hess B, Ryal RL, Kavanagh JP, Khan SR, Kok DJ, Rodgers AL, Tiselius HG. Methods for measuring crystallization in urolithiasis research - why, how and when? Eur Urol 2001; 40: 220-230
54      Advisory Board European Urolithiasis Research. Possibilities for prevention of recurrent calcium stone formation. Principles for the metabolic evaluation of patients with calcium stone disease. BJU int, 2001; 88: 158-168.
55      Mathoera RB, Kok DJ, Visser WJ, Verduin CM, Nijman RJ. Cellular membrane associated mucins in artificial urine as mediators of crystal adhesion; an in-vitro enterocystoplasty model. J Urol 2001; 166: 2329-2336
56      Dey J, Creighton A, Lindberg JS, Fuselier HA, Kok DJ, Cole FE. Estrogen replacement increased citrate and calcium excretion rates in postmenopausal women with recurrent urolithiasis. J Urol 2002; 167: 169-171
57      Kok DJ. Clinical implications of physicochemistry of stone formation. Endocrine Metab Clin N AM 2002; 31:855-67.
58      Mathoera RB, Kok DJ, Verduin K, Nijman RJM. Pathological and therapeutical significance of cellular invasion by Proteus Mirabilis in an enterocystoplasty infection stone model. Infect Immun 2002; 70: 7022-7032.
59      Asselman M, Verkoelen CF. Crystal-cell interaction in the pathogenesis of kidney stone disease. Curr Opin Urol. 2002; 12: 271-6.
60      Schepers MS, van der Boom BG, Romijn JC, Schröder FH, Verkoelen CF. Urinary crystallization inhibitors do not prevent crystal binding. J Urol. 2002; 167:1844-7.
61      Turan T, v Harten JG, de Water R, Tuncay OL, Kok DJ. Is enalapril adequate for the prevention of renal tissue damage caused by unilateral obstruction and/or hyperoxaluria? Urol Res, 2003 31: 212-217.
62      De Jong BWD, de Gouveia Brazao CA, Stoop H, Oosterhuis JW, Puppels GJ, Weber RFA, Looijenga LHJ, Kok DJ.Identification of testicular microlithiasis by Raman spectroscopy: intratubular located hydroxyapatite. J Urol, 2004, 171: 92-6.
63      Asselman M, Verhulst A, De Broe ME, Verkoelen CF. Calcium oxalate crystal adherence to hyaluronan-, osteopontin-, and CD44-expressing injured/ regenerating tubular epithelial cells in rat kidneys. J Am Soc Nephrol. 2003; 14: 3155-66.
64      Schepers MS, Asselman M, Duim RA, Romijn JC, Schröder FH, Verkoelen CF. Pericellular matrix formation by renal tubule epithelial cells in relation to crystal binding. Nephron Exp Nephrol. 2003; 94: e103-12.
65      Schepers MS, Duim RA, Asselman M, Romijn JC, Schröder FH, Verkoelen CF. Internalization of calcium oxalate crystals by renal tubular cells: a nephron segment-specific process? Kidney Int. 2003; 64: 493-500.
66      Verhulst A, Asselman M, Persy VP, Schepers MS, Helbert MF, Verkoelen CF, De Broe ME. Crystal retention capacity of cells in the human nephron: involvement of CD44 and its ligands hyaluronic acid and osteopontin in the transition of a crystal binding- into a nonadherent epithelium. J Am Soc Nephrol. 2003; 14: 107-15.
67      Khan SR, Kok DJ. Modulators of urinary stone formation. Front Bioscience 2004, 1;9: 1450-82
68      Verkoelen CF, Schepers MS, van Ballegooijen ES, Bangma CH Effects of luminal oxalate or calcium oxalate on renal tubular cells in culture. Urol Res. 2005; 33: 321-8.
69      Schepers MS, van Ballegooijen ES, Bangma CH, Verkoelen CF. Oxalate is toxic to renal tubular cells only at supraphysiologic concentrations. Kidney Int. 2005; 68: 1660-9.
70      Verhulst A, Asselman M, De Naeyer S, Vervaet BA, Mengel M, Gwinner W, D'Haese PC, Verkoelen CF, De Broe ME. Preconditioning of the distal tubular epithelium of the human kidney precedes nephrocalcinosis. Kidney Int. 2005; 68: 1643-7.
71      Schepers MS, van Ballegooijen ES, Bangma CH, Verkoelen CF. Crystals cause acute necrotic cell death in renal proximal tubule cells, but not in collecting tubule cells. Kidney Int. 2005; 68: 1543-53.
72      Asselman M, Verhulst A, Van Ballegooijen ES, Bangma CH, Verkoelen CF, De Broe ME. Hyaluronan is apically secreted and expressed by proliferating or regenerating renal tubular cells. Kidney Int. 2005; 68: 71-83.
73      Boormans JL, Scheepe JR, Verkoelen CF, Verhagen PC. Percutaneous nephrolithotomy for treating renal calculi in children. BJU Int. 2005; 95: 631-4.
74      Verkoelen CF. Crystal retention in renal stone disease: a crucial role for the glycosaminoglycan hyaluronan? J Am Soc Nephrol. 2006; 17: 1673-87.
75      Salahuddin S, Kok DJ, Buchholz NN. Influence of body temperature on indinavir crystallization under loop of Henle conditions. J Antimicrob Chemother. 2007; Jan; 59: 114-7. Epub 2006 Nov 9.
76      Kummeling MTM, de Jong BWD, Laffeber C, Kok DJ, Verhagen PCMS, van Leenders GJLH, van Schaik RHN, van Woerden CS, Verhulst A, Verkoelen CF. Tubular and interstitial nephrocalcinosis. J Urol 2007; 178: 1097-1103
77      Verkoelen CF, Verhulst A.Proposed mechanisms in renal tubular crystal retention. Kidney Int. 2007; 72: 13-8.
78      Asselman M, Verkoelen CF. Fructose intake as a risk factor for kidney stone disease. Kidney Int. 2008; 73: 139-40.
Boeken, hoofdstukken in lesboeken en proefschriften
1Kok DJ. The role of crystallization processes in calcium oxalate urolithiasis. Proefschtift, Universiteit Leiden 30-1-1991.
2Hess B, Kok DJ. Nucleation, Growth and aggregation of stone forming crystals.             In: Kidney stones: Medical and surgical management. Coe FL, Favus M, Pak CYC, Parks J and Preminger G. (eds.) Lippincott-Raven. Philidelphia. 1996;                        Chapter 1; 3-32. ISBN 0-7817-0263-1
3Kok DJ. Inhibitors of calcium oxalate Calcium oxalate in biological systems. Editor Khan SR, CRC press of Boca Raton, Fl USA. 1995, chapter 2, pp 23-36.
4The Involvement of renal tubule epithelial cells in the pathophysiology of calcium oxalate nephrolithiasis. C.F. Verkoelen. Proefschrift EramsusMC 25-22-1998.
5EUROLITHIASIS. editors: DJ Kok, HC Romijn, PCMS Verhagen, CF Verkoelen. Shaker Verlag, Maastricht 2001. ISBN 90-423-0171-6B
6Handling of oxalate and calcium oxalate by renal tubule epithelial cells. M Schepers. Proefschrift ErasmusMC 20-4-2005
7Khan SR, Kok DJ. Modulators of crystallization of stone salts. In: Current clinical urology, Urinary Stone disease, a practical guide to medical and surgical management. Eds. M.L. Stoller, M.V. Meng. Humana press Inc, Totowa, NJ, 2007. chapter 10
8 Hyaluronan biology and regulation in renal tubular epithelial cells and its role in kidney stone disease. M Asselman. Preofschrift ErasmusMC 3-9-2008.
Nationale pers
1      NRC-Handelsblad, December 4, 1986
2      Volkskrant, December 7, 1986
3      Cicero, September 15, 1989
4      Telegraaf, September 23, 1989
5      Telegraaf, Januari 29, 1991
6      Leidsch Dagblad, Januari 29, 1991
7      Dia 1991
8      Dia 1992
9      Scoop 2001
10 Scoop 2001
11 AD2008    
Nationale TV
1         NOS-laat, October 3, 1989
2         NOS-Journaal, October 3, 1989
For further background on the investigators: